Brooking no excuses: university staff and students are encouraged to develop their engagement

Brooking no excuses: university staff and students are encouraged to develop their engagement This paper will explore the internal and external factors that have prompted the University of East Anglia's decision to give Public Engagement into a more central role within the Universities Corporate Plan. It will illustrate how the SEARCH Action Learning Programme facilitated the design, implementation and delivery of new Staff and Student Development Programmes that aim to provide the confidence, skills and mentorship that will encourage staff to develop their engagement activities. We will use a SWOT analysis to discuss the strengths, weaknesses, opportunities and threats of the Public Engagement Practitioner. As part of this, we will explore how many of the issues we face as Science communicators with the public are similar to issues encountered by Communicators within the Arts and Humanities disciplines. Finally we will outline and detail our future plans, opportunities and vision that will enable us to move this agenda forward

Reflections from Participants

The Road Ahead: Public Dialogue on Science and Technology brings together some of the UK’s leading thinkers and practitioners in science and society to ask where we have got to, how we have got here, why we are doing what we are doing and what we should do next. The collection of essays aims to provide policy makers and dialogue deliverers with insights into how dialogue could be used in the future to strengthen the links between science and society. It is introduced by Professor Kathy Sykes, one of the UK’s best known science communicators, who is also the head of the Sciencewise-ERC Steering Group, and Jack Stilgoe, a DEMOS associate, who compiled the collection

Microbiology survey shows authors have most to gain from peer review

In the week that an international team of publishers, science communicators and other scholarly organisations launch the second international Peer Review Week, the preliminary findings from our new survey reveal that authors gain more from peer review than the people who do the actual review

Promoting Microbiology Education Through the iGEM Synthetic Biology Competition

Synthetic biology has developed rapidly in the 21st century. It covers a range of scientific disciplines that incorporate principles from engineering to take advantage of and improve biological systems, often applied to specific problems. Methods important in this subject area include the systematic design and testing of biological systems and, here, we describe how synthetic biology projects frequently develop microbiology skills and education. Synthetic biology research has huge potential in biotechnology and medicine, which brings important ethical and moral issues to address, offering learning opportunities about the wider impact of microbiological research. Synthetic biology projects have developed into wide-ranging training and educational experiences through iGEM, the International Genetically Engineered Machines competition. Elements of the competition are judged against specific criteria and teams can win medals and prizes across several categories. Collaboration is an important element of iGEM and all DNA constructs synthesised by iGEM teams are made available to all researchers through the Registry for Standard Biological Parts. An overview of microbiological developments in the iGEM competition is provided. This review is targeted at educators that focus on microbiology and synthetic biology, but will also be of value to undergraduate and postgraduate students with an interest in this exciting subject area

Characterization of a temperature-sensitive DNA ligase from Escherichia coli

DNA ligases are essential enzymes in cells due to their ability to join DNA strand breaks formed during DNA replication. Several temperature-sensitive mutant strains of Escherichia coli, including strain GR501, have been described which can be complemented by functional DNA ligases. Here, it is shown that the ligA251 mutation in E. coli GR501 strain is a cytosine to thymine transition at base 43, which results in a substitution of leucine by phenylalanine at residue 15. The protein product of this gene (LigA251) is accumulated to a similar level at permissive and non-permissive temperatures. Compared to wild-type LigA, at 20 °C purified LigA251 has 20-fold lower ligation activity in vitro, and its activity is reduced further at 42 °C, resulting in 60-fold lower ligation activity than wild-type LigA. It is proposed that the mutation in LigA251 affects the structure of the N-terminal region of LigA. The resulting decrease in DNA ligase activity at the non-permissive temperature is likely to occur as the result of a conformational change that reduces the rate of adenylation of the ligase

Raising awareness of antimicrobial resistance among the general public in the UK: the role of public engagement activities

In response to the accepted risk of emerging antimicrobial resistance, many organizations and institutions have developed and delivered events and activities designed to raise awareness of the issue and to change the behaviour of the intended audience. However, few of these events for a general public audience are documented or able to be sourced by those who might wish to repeat, adapt or modify, particularly those events that are successful. ‘Insider knowledge’ appears to be the best search tool. Moreover, evaluation of the success or impact of the event is rarely published. It would be useful if there were a ‘hub’ where descriptions of such activities could be deposited, enabling the building of a significant resource with real academic value

Bacillus subtilis YxaG is a novel Fe-containing quercetin 2,3-dioxygenase

AbstractThe Bacillus subtilis genome contains genes for three hypothetical proteins belonging to the bicupin family, two of which we have previously shown to be Mn(II)-dependent oxalate decarboxylases. We have now shown that the third, YxaG, exhibits quercetin 2,3-dioxygenase activity and that it contains Fe ions. This contrasts with the eukaryotic enzyme which contains a Cu ion. YxaG is the first prokaryotic carbon monoxide-forming enzyme that utilises a flavonol to be characterised and is only the second example of a prokaryotic dioxygenolytic carbon monoxide-forming enzyme known to contain a cofactor. It is proposed to rename the B. subtilis gene qdoI